Climate change significantly affects the water use efficiency (WUE) and yield of field crops. This study evaluates the impacts of climate change on biological yield, grain yield, water consumption, and WUE of two barley genotypes, Goharan and Reyhan 03, under autumn and spring planting regimes using the CERES-Barley model within the Decision Support System for Agrotechnology Transfer (DSSAT) software. Data provided for model calibration and validation were sourced from the field experiments conducted at the Isfahan University of Technology research farm located in Najafabad, Iran. Meteorological data for the period of 2003 to 2016 were obtained from the Najafabad weather station, while future climate projections for 2020–2050 were generated using the MarkSim weather generator under the Representative Concentration Pathway (RCP) 8.5 scenario. Planting dates were analyzed within a ±35-day window relative to baseline dates of October 22 for autumn and March 3 for spring. The model demonstrated high accuracy in calibrating key traits, including days to anthesis, days to maturity, leaf area index, grain yield, and biological yield. Elevated temperatures associated with climate change reduced grain and biological yields across both planting seasons, with biological yield exhibiting a more pronounced decline, particularly under spring planting. During the 2040–2050 period, water consumption peaked at 387.5 mm for Goharan in autumn planting, while spring planting recorded a minimum of 239 mm for Reyhan 03. Delaying autumn planting by 20–25 days enhanced WUE, while planting earlier in the spring )10–20 days (improved WUE by exploiting cooler temperatures. Evapotranspiration increased by 399 mm in autumn but decreased by 267 mm in spring. The earlier-maturing Reyhan 03 genotype demonstrated smaller yield losses in spring planting due to climate change. The findings of this study suggest that programmed adjustments to planting dates may mitigate the adverse impacts of climate change on barley production, thereby enhancing sustainability.