Greenhouse gas emissions and achieving acceptable water and energy efficiency are among the most important challenges facing the agricultural sector. The objective of the current research was to investigate the indicators of water physical and economic productivity and energy of wheat in Khorasan Razavi Province. To evaluate these indicators, a questionnaire was used in this research. A total of 200 questionnaires, including 50 for each city, were distributed, and the amount of input consumption and production was collected. The results showed that the physical productivity of water in the plains of Mashhad, Torbat Jam, Taybad, and Bakharz was 0.57, 0.72, 0.7, and 0.46 kg/m3, respectively. Also, the results showed that the highest Energy efficiency and energy productivity were 2.18 and 0.148 kg/MJ, respectively, for the Taybad Plain, and the highest specific energy was 10.92 MJ/kg for the Bakharz Plain. The highest (1539/68 kg/ha) and lowest (964/79 kg/ha) greenhouse gas emissions were obtained in the Mashhad and Taybad plains, respectively. The overall results showed that crop yield in relatively arid areas such as Torbat-e Jam and Taybad is higher than in semi-arid areas with higher altitudes, similar to Mashhad and Bakhrez.