The application of coagulation processes for the treatment of stone quarrying wastewater has increased considerably in recent years. However, limited information is available regarding the appropriate coagulant type, optimum dosage, and pollutant removal efficiency. This study aimed to evaluate the performance of several organic and inorganic coagulants, including polyaluminum chloride (PAC), aluminum sulfate (alum), ferric chloride, zeolite, anionic polyacrylamide (APAM), and cationic polyacrylamide (CPAM), for the treatment of wastewater generated from different stone-processing industries (granite, marble, and travertine) located in Mahmoudabad Industrial Town, Isfahan, Iran. In this experimental study, the effects of coagulant dosage and mixing conditions on the treatment of four types of raw wastewater were investigated using the Response Surface Methodology (RSM). The results indicated that the optimum dosages of zeolite, ferric chloride, and PAC were 200 mg/L, while the optimum dosage of aluminum sulfate was 100 mg/L. For both anionic and cationic polyacrylamide, the optimum dosage was 0.5 mg/L. APAM, CPAM, and PAC exhibited the highest treatment performance among the tested coagulants, respectively. Zeolite showed the lowest removal efficiency (16.5%) for white travertine wastewater, whereas APAM achieved the highest removal efficiency (98.1%) for marble wastewater. Furthermore, analysis of the operational parameters demonstrated that mixing speed and coagulant dosage had the greatest influence on turbidity removal, whereas mixing time showed a comparatively lower effect. Overall, polymer-based coagulants, particularly APAM and CPAM, proved to be highly effective for the treatment of stone-processing wastewater