Optimal use of water resources seem to be necessary due to climate change and the recent drought conditions. One of the most important and effective management strategies is increasing water productivity in agriculture. Irrigation method and the use of different levels of nitrogen fertilizer are the effective factors in increasing the water productivity. Therefore, this study was conducted to investigate the effect of the irrigation method and nitrogen fertilizer on the harvest index and water productivity of two wheat cultivars with 36 treatments as a split-split plot based on a completely randomized design with three replications in the research farm of Natural Resources and Agricultural Research Center of Kashmar, during the 2018-2019 time period. The treatments were two irrigation methods including end blocked border and drip irrigation (tape) as  the main plots, three levels of the nitrogen fertilizer from urea source including 0, 50 and 100 kg/ha as the  sub plots and two cultivars of wheat including Pishgam and Sirvan as the sub-sub plots. The results showed that by changing the border irrigation method to the drip irrigation (tape) method, the harvest index and water productivity were increasesignificantly. The results also showed that grain yield and its components, including harvest index and water productivity, had no significant difference in 50 and 100 kg/ha nitrogen levels. On the other hand, grain yield and its components, harvest index and water productivity, were significantly higher in the Sirvan cultivar rather than the Pishgam one (P<0.01). According to the results obtained from this study, the drip irrigation method, 50 kg/ha nitrogen level and Sirvan cultivar could be recommended for the study region.