In this research, to locate and prioritize suitable areas for flood spreading in Mashhad plain, 10 criteria were used including land use, slope, alluvium thickness, distance to well, distance to subterranean, distance from the village, water table drawdown, permeability coefficient, electrical conductivity, and drainage density. Weighting process was done by Analytic Network Process (ANP) and fuzzy logic. After preparing and weighting the maps of all appropriate measures for locating suitable areas of flood spreading maps based on fuzzy logic and analytic network process model, the final map was prepared for prioritizing suitable areas for flood spreading. Then by applying the limiting layer that is a combination of three criteria of land use, slope and geomorphology, the final map of suitable areas for flood spreading was prepared and prioritized. The results showed that among the 10 factors influencing flood spreading, the thickness of alluvium criteria by weight of 0.27 was identified as the most effective layer in suitable areas for flood spreading. Most of the suitable regions located in slope less than 3% that represents its considerable impact in implementation of flood spreading. Mashhad plain potential for flood spreading, after removing exception areas (40.8% of total area), were defined in four inappropriate, relatively appropriate, appropriate and perfectly appropriate classes, that include 2.7, 25.9, 26.5 and 1.5% of the plain area, respectively.