In the ICSSDOM simulation-optimization model, simulated annealing algorithm is combined with a hydrodynamic simulation model named ICSS. In this model the ability of weighting of indicators is also considered. In this study, using this model the performance of the S-L-R5 canal in the DEZ irrigation network was evaluated in a period of 10 days. With presenting a proposed method for weighting the indicators and its various options, using parametric sensitivity analysis, optimal adjustment of intake and check structures was obtained. It was found if the coefficient of each index is selected as a direct ratio of the ideal improvement potential of the indicator, the percentage of the improvement is more than the other investigated options. In addition, due to the interaction of the indicators in the multi-objective functions, the consistency of the weighting method with the nature of the optimization problem in this study has been shown. Statistically, the adequacy of the 10-day period of study was confirmed. The model validation with mathematical asymptote method shows 6% error which indicates the model is valid. For example, on the first day, based on the option three (The optimal option), the optimal gate opening for 5 intakes and one check control was between 3.9 to 14.7 Cm. In this condition optimal delivery was between 46 to 178 liters per second.